Since the opening of the first gallery in Paris in 1993, followed by the one in Brussels in 2008 and a second space in Paris in 2013, Nathalie Obadia has exhibited emerging and recognized artists of the international contemporary art scene. In the fall of 2021, Galerie Nathalie Obadia has opened a new space in the Matignon-Saint-Honoré district in Paris.
For many years, the gallery has also participated in the rediscovery of deceased artists like Martin Barré, Josep Grau-Garriga, and Seydou Keita.